Fontana-Masson Stain Kit
- Fontana-Masson is a Silver Reduction Stain. It is the GOLD STANDARD stain to demonstrate Melanin pigment and Argentaffin cells in tissue sections. Melanin reduces silver nitrate to metallic black silver.
- Most sensitive stain for Melanoma diagnosis.
- Gold Standard for Melanin Demonstration
- Very High Sensitivity – Even small amount of melanin detected
- Differentiates Melanin from other brown pigments like Hemosiderin, Lipofuscin
- Ready-to-Use Solutions
- Stable for 12 Months at 2-8°C
- No Heating Required
- Melanin has strong Reducing Property.
- What It Stains:
- Interpretation for Pathologist:
-
1. Tissue section incubated in Ammoniacal Silver Nitrate Solution
2. Melanin / Argentaffin granules reduce Silver Nitrate to Metallic Silver
3. Melanin / Argentaffin Cells = Jet Black
4. Background = Pink to Red (Nuclear Fast Red counterstain)
5. No external reducer needed – Melanin itself is the reducer.
| Structure | Color Result |
|---|---|
| Melanin | Jet Black |
| Argentaffin Granules | Black |
| Nuclei / Background | Pink / Red |
-
1. Melanin Present (Black) =Melanoma, Melanocytic nevus, Melanosis
2. Melanin Absent = Amelanotic tumor, other pigments
3. Argentaffin Positive = Carcinoid Tumor / NET
- Must for Melanoma Diagnosis:Confirms melanocytic origin of tumor – most critical cancer diagnosis
- Saves IHC Cost: Before doing expensive S100 / Melan-A IHC, Fontana-Masson gives quick confirmation
- Differentiates Pigments: PAS / Perl’s negative, Fontana positive = 100% Melanin. Avoids misdiagnosis of Hemosiderin as Melanin
- Essential for Carcinoid / NET Tumor: Argentaffin cells demonstration
- NABL Compliance: Required special stain for NABL accredited histopathology labs
- Fast & Economical: Result in 60 minutes, at 1/10th cost of IHC
- Why to Order Fontana-Masson:
-
1. Suspected Melanoma – Skin, Eye, Oral Cavity
2. Pigmented Lesions – Nevus vs Melanoma
3. Carcinoid Tumor / Neuroendocrine Tumor (NET)
4. Any tumor with brown pigment
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