Myeloperoxidase (MPO) Stain kit
For Cytochemical Identification of Myeloid cells
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Categories : Digital-Optimized H&E & Special Stains, IHC Compatible Histopathology Reagents (Fix to Mount)
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Myeloperoxidase (MPO) Stain Kit is a cytochemical staining system designed for the demonstration of myeloperoxidase activity in blood and bone marrow smears. MPO is a characteristic enzyme of cells of the myeloid lineage and is particularly useful in the cytochemical evaluation and classification of leukemic and other hematological disorders.
- Designed for cytochemical demonstration of myeloperoxidase activity
- Suitable for peripheral blood and bone marrow smears
- Produces distinct cytoplasmic staining in MPO-positive cells
- Useful for identifying cells of myeloid differentiation
- Supports cytochemical evaluation of hematological specimens
- Suitable for routine hematology laboratories and diagnostic applications
- Convenient kit format for standardized staining procedures
- Appropriate for microscopy-based morphological assessment
The MPO reaction is based on the enzymatic activity of myeloperoxidase present in the cytoplasmic granules of myeloid cells. In the presence of an appropriate peroxide substrate and chromogenic reagent, MPO catalyzes an oxidation reaction that produces an insoluble coloured reaction product at sites of enzyme activity. The resulting cytoplasmic staining allows MPO-positive cells to be identified microscopically.
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1. Applications:
- Demonstration of myeloperoxidase activity in blood smears
- Evaluation of bone marrow smears
- Identification of myeloid cell differentiation
- Cytochemical assessment of immature and mature myeloid cells
- Supportive investigation of acute leukemias and other hematological disorders
- Teaching and research in hematology and cytochemistry
- Provides a practical cytochemical method for demonstrating MPO activity
- Helps differentiate MPO-positive myeloid cells from MPO-negative cell populations
- Supports morphological and cytochemical evaluation of hematological specimens
- Provides visible reaction products for convenient microscopic interpretation
- Suitable for routine laboratory workflows
- Helps complement morphological examination and other hematological investigations
- Interpretation
MPO-positive cells demonstrate a characteristic coloured cytoplasmic reaction, particularly in cells containing myeloid granules. The staining result should be interpreted together with peripheral blood/bone marrow morphology and other laboratory findings rather than used as a standalone diagnostic test.
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